李国
博士 副教授
李国，博士研究生，校聘副教授。2020年博士毕业于南京邮电大学生物电子学专业，师从国家杰青赵强教授。2020年9月加入南通大学主站|亚博2021vip网页版，主要从事有机小分子和共轭聚合物的设计、合成及其在肿瘤诊疗中的应用研究。迄今为止，在Analytical Chemistry、ACS Applied Materials & Interfaces、Research、Journal of Materials Chemistry B、Journal of Organometallic Chemistry、Nanophotonics in Biomedical Engineering等国际著名期刊上发表多篇学术论文和英文书稿。受邀担任Anal. Chem, ACS Appl. Mater. Interfaces, Chem. Commun等多个著名学术期刊审稿人。目前主持及参与国家自然科学基金两项。
主持项目：
国家自然科学基金青年基金一项 主持
国家自然科学面上项目一项主要参与人
研究方向：
有机小分子：肿瘤微环境响应型有机小分子荧光探针的设计、合成及其在肿瘤检测和协同治疗中的应用研究。
共轭聚合物：构建可用于肿瘤检测和光动力光热协调治疗的共轭聚合物光疗试剂，利用共轭聚合物特殊性能开发其在细胞焦亡和免疫治疗中的应用。
代表论文:
(1) Guo Li, Xiangxiang Zhang, Weili Zhao, Weiwei Zhao, Feiyang Li, Kang Xiao, Qi Yu, Shujuan Liu*, and Qiang Zhao*, Stable and well-organized near-infrared (NIR) platinum(II)-acetylide metallacycles mediated cancer phototherapy, ACS Appl. Mater. Interfaces,2020, 12, 20180-20190.
(2) Guo Li, Ruyi Zhou, Weili Zhao, Bo Yu, Jie Zhou, Shujuan Liu*, Wei Huang*, and Qiang Zhao*, Photothermally-responsive conjugated polymeric singlet oxygen carrier for phase-change-controlled and sustainable phototherapy for hypoxic tumor,Research,2020, 5351848.
(3) Guo Li, Wenbo Hu, Menglong Zhao, Weili Zhao, Feiyang Li, Shujuan Liu*, Wei Huang, and Qiang Zhao*, Rational design of near-infrared platinum(II)-acetylide conjugated polymers for photoacoustic imaging-guided synergistic phototherapy under 808 nm irradiation,J. Mater. Chem. B,2020, 8, 7356-7364.
(4) Guo Li; Qi Wang, Jinxia Liu, Mingmin Wu, Haiwei Ji, Yuling Qin*, Xiaobo Zhou* and Li Wu*, Innovative strategies for enhanced tumor photodynamic therapy, J. Mater. Chem. B,2021, 9, 7347-7370.
(5) Linfeng Zhao, Can Zhao, Jiasheng Zhou , Yuling Qin, Guo Li*, Li Wu* and Xiaobo Zhou*, Conjugated polymers-based luminescent probes for ratiometric detection of biomolecules, J. Mater. Chem. B,2022, doi:10.1039/D2TB00937D.
(6) Guo Li, Tianci Huang, Mingjuan Xie, Xiangxiang Zhang, Qi Yu, Shujuan Liu*, Tianshe Yang, and Qiang Zhao*, A platinum(II)-acetylide-based conjugated polyelectrolyte for hypoxia imaging via ratiometric and time-resolved luminescence microscopy, J. Organomet. Chem, 2019, 879: 144-149.
(7) Guo Li; Tianshe Yang, Weiwei Zhao, Shujuan Liu, Wei Huang, Qiang Zhao*, Luminescent conjugated polymer dots for biomedical applications, Springer Book Frontiers of Nanophotonics in Biomedical Engineering. (chapter)
(8) Jinxia Liu, Xiaodi Liu, Huanhuan Chen, Luxia Yang, Aiting Cai, Haiwei Ji*, Qi Wang, Xiaobo Zhou, Guo Li, Mingmin Wu, Yuling Qin* and Li Wu*, Bifunctional pdots-based novel ECL nanoprobe with qualitative and quantitative dual signal amplification characteristics for trace cytokine analysis. Anal. Chem. 2022, 94, 7115-7122.
(9) Qi Yu, Tianci Huang, Chao Liu, Menglong Zhao, Mingjuan Xie, Guo Li, Shujuan Liu, Wei Huang* and Qiang Zhao*, Oxygen self-sufficient NIR-activatable liposomes for tumor hypoxia regulation and photodynamic therapy, Chem. Sci. 2019, 10, 9091-9098.
(10) Jinxia Liu, Xiaodi Liu, Luxia Yang, Aiting Cai, Xiaobo Zhou*, Chu Zhou, Guo Li, Qi Wang, Mingmin Wu, Li Wu, Haiwei Ji* and Yuling Qin*,A highly sensitive electrochemical cytosensor based on a triple signal amplification strategy using both nanozyme and DNAzyme, J. Mater. Chem. B,2022, 10, 700-706.
(11) Xue Liu, Guo Li, Mingjuan Xie, Song Guo, Weili Zhao, Feiyang Li, Shujuan Liu*, and Qiang Zhao*, Rational design of type I photosensitizers based on Ru(ii) complexes for effective photodynamic therapy under hypoxia, Dalton Trans., 2020,49, 11192-11200.
发明专利:
1. 赵强,刘淑娟,李国,黄维,张享享，一种双发射共轭聚合物乏氧探针的制备及应用，中国，专利号：ZL201810174307.1。
2. 赵强,刘淑娟,李国,黄维,张享享, 一种近红外共轭聚合物及其制备方法和应用，中国，专利号：ZL201810198193.4。